Sarafotoxin S6c is primarily used in research settings to study the endothelin system, particularly its interaction with endothelin receptors. It acts as a selective agonist for the endothelin B (ETB) receptor, making it a valuable tool for investigating the physiological and pathological roles of this receptor in various tissues. Researchers utilize it to explore vascular function, as ETB receptors play a significant role in vasodilation and vasoconstriction. Additionally, it is employed in studies related to cardiovascular diseases, pulmonary hypertension, and renal function, providing insights into receptor signaling pathways and potential therapeutic targets. Its specificity for the ETB receptor also aids in distinguishing the effects of ETB from other endothelin receptor subtypes in experimental models.