[(3aS,4R,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[2,3-b]furan-4-yl] N-[(2-fluorophenyl)methylamino]carbamate

95%

Reagent Code: #54773
fingerprint
CAS Number 1003870-29-8

science Other reagents with same CAS 1003870-29-8

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 296.29 g/mol
Formula C₁₄H₁₇FN₂O₄
inventory_2 Storage & Handling
Storage 2-8°C, dry, sealed

description Product Description

This compound serves as a crucial intermediate in medicinal chemistry, particularly in the synthesis of HIV protease inhibitors such as Darunavir. It is employed in the development of antiretroviral drugs for treating HIV/AIDS, where it enhances the binding affinity to the viral protease enzyme, improving efficacy against drug-resistant strains. The unique bis-tetrahydrofuran structure provides rigidity and optimal positioning for hydrogen bonding interactions within the enzyme's active site. Additionally, the (2-fluorophenyl)methylamino group contributes to lipophilicity, aiding in bioavailability and cellular uptake. Research also explores its potential in other protease-targeted therapies, though its primary application remains in antiviral pharmaceuticals.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 5mg
10-20 days ฿41,940.00

Cart

No products

Subtotal: 0.00
Total 0.00 THB
[(3aS,4R,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[2,3-b]furan-4-yl] N-[(2-fluorophenyl)methylamino]carbamate
No image available

This compound serves as a crucial intermediate in medicinal chemistry, particularly in the synthesis of HIV protease inhibitors such as Darunavir. It is employed in the development of antiretroviral drugs for treating HIV/AIDS, where it enhances the binding affinity to the viral protease enzyme, improving efficacy against drug-resistant strains. The unique bis-tetrahydrofuran structure provides rigidity and optimal positioning for hydrogen bonding interactions within the enzyme's active site. Additionall

This compound serves as a crucial intermediate in medicinal chemistry, particularly in the synthesis of HIV protease inhibitors such as Darunavir. It is employed in the development of antiretroviral drugs for treating HIV/AIDS, where it enhances the binding affinity to the viral protease enzyme, improving efficacy against drug-resistant strains. The unique bis-tetrahydrofuran structure provides rigidity and optimal positioning for hydrogen bonding interactions within the enzyme's active site. Additionally, the (2-fluorophenyl)methylamino group contributes to lipophilicity, aiding in bioavailability and cellular uptake. Research also explores its potential in other protease-targeted therapies, though its primary application remains in antiviral pharmaceuticals.

Mechanism -
Appearance -
Longevity -
Strength -
Storage -
Shelf Life -
Allergen(s) -
Dosage (Range) -
Dosage (Per Day) -
Mix Method -
Heat Resistance -
Stable in pH range -
Solubility -
Product Types -
INCI -

Purchase History for

Loading purchase history...