[(3aS,4R,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[2,3-b]furan-4-yl] N-[(2-fluorophenyl)methylamino]carbamate
95%
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This compound serves as a crucial intermediate in medicinal chemistry, particularly in the synthesis of HIV protease inhibitors such as Darunavir. It is employed in the development of antiretroviral drugs for treating HIV/AIDS, where it enhances the binding affinity to the viral protease enzyme, improving efficacy against drug-resistant strains. The unique bis-tetrahydrofuran structure provides rigidity and optimal positioning for hydrogen bonding interactions within the enzyme's active site. Additionally, the (2-fluorophenyl)methylamino group contributes to lipophilicity, aiding in bioavailability and cellular uptake. Research also explores its potential in other protease-targeted therapies, though its primary application remains in antiviral pharmaceuticals.
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