4-Chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine
98%
Reagent
Code: #192438
CAS Number
2189684-53-3
blur_circular Chemical Specifications
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Molecular Information
Weight
375.58 g/mol
Formula
C₁₅H₁₈BClF₃N₃O₂
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Registry Numbers
MDL Number
MFCD34471206
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Physical Properties
Boiling Point
462.5±45.0 °C(Predicted)
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Storage & Handling
Density
1.39±0.1 g/cm3(Predicted)
Storage
2-8°C, light-proof, inert gas
description Product Description
Used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of biologically active indazole derivatives. Its boronate ester group enables efficient carbon-carbon bond formation, making it valuable in pharmaceutical research, particularly in the development of kinase inhibitors and other targeted therapies. The trifluoroethyl and chloro substituents enhance reactivity and selectivity in coupling processes, allowing for the construction of complex molecular architectures found in drug candidates. Commonly employed in medicinal chemistry for lead optimization and library synthesis.
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