6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole
95%
Reagent
Code: #192321
CAS Number
2407852-20-2
blur_circular Chemical Specifications
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Molecular Information
Weight
404.38 g/mol
Formula
C₂₀H₃₃BN₂O₄Si
thermostat
Physical Properties
Boiling Point
493.1±45.0 °C(Predicted)
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Storage & Handling
Storage
2-8°C, Sealed, Inert Gas
description Product Description
Used as a key intermediate in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex indazole derivatives. Its boronate ester group enables efficient carbon-carbon bond formation, making it valuable in pharmaceutical research, particularly in the development of kinase inhibitors and other bioactive molecules. The SEM protecting group on the indazole nitrogen ensures stability during reactions and can be selectively removed under mild acidic conditions, allowing for further functionalization. This compound is especially useful in medicinal chemistry for constructing libraries of heterocyclic compounds in drug discovery programs.
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