Mal-PEG2-NH2 (TFA) is widely used in bioconjugation and drug delivery applications. It serves as a linker molecule, enabling the attachment of therapeutic agents, proteins, or peptides to other biomolecules or nanoparticles. The maleimide group reacts selectively with thiol groups, facilitating stable covalent bonds, while the amine group allows for further functionalization or coupling with carboxyl groups. This compound is particularly valuable in antibody-drug conjugates (ADCs), where it helps in creating targeted cancer therapies by linking cytotoxic drugs to antibodies. Additionally, it is employed in surface modification of nanoparticles to enhance their biocompatibility and targeting efficiency. Its water solubility and stability make it a preferred choice in various biomedical and pharmaceutical research applications.