Poly(ethylene glycol) bis(carboxymethyl) ether is widely used in various industrial and scientific applications due to its unique properties. It serves as a versatile crosslinking agent in the synthesis of hydrogels, which are essential in drug delivery systems, wound care, and tissue engineering. Its bifunctional nature allows it to form stable networks, enhancing the mechanical strength and biocompatibility of hydrogels.

In bioconjugation, this compound is employed to modify proteins, peptides, and other biomolecules, improving their solubility, stability, and circulation time in biological systems. This makes it valuable in pharmaceutical development, particularly for creating long-acting therapeutic agents.

Additionally, it is utilized in the production of functionalized polymers and coatings, where its carboxyl groups enable further chemical modifications. This property is beneficial in creating tailored materials for applications in adhesives, surface treatments, and nanotechnology.

Its role as a chelating agent is also notable, particularly in metal ion binding and removal processes, making it useful in water treatment and environmental remediation. Overall, its multifunctionality and adaptability make it a critical component in advanced material science and biotechnology.