HO-PEG-AC is widely used in bioconjugation and drug delivery systems due to its reactive acrylate (AC) group and hydrophilic polyethylene glycol (PEG) chain. The acrylate group allows for efficient covalent bonding with thiol-containing molecules, making it valuable for modifying proteins, peptides, and other biomolecules. This property is particularly useful in creating targeted drug delivery systems, where the PEG component enhances solubility, reduces immunogenicity, and prolongs circulation time in the body. Additionally, HO-PEG-AC is employed in the development of hydrogels and biomaterials for tissue engineering, where its ability to form cross-linked networks under mild conditions is advantageous. It is also utilized in surface modification of nanoparticles to improve their stability and biocompatibility for therapeutic applications.