SH-PEG-OH is widely used in bioconjugation and surface modification due to its thiol and hydroxyl functional groups. The thiol group allows for strong covalent bonding with gold, silver, or other metal surfaces, making it valuable in creating self-assembled monolayers (SAMs) for biosensors and diagnostic devices. The hydroxyl group provides a site for further chemical modifications, enabling the attachment of biomolecules like proteins, peptides, or drugs. This chemical is also employed in drug delivery systems to enhance solubility, stability, and biocompatibility of therapeutic agents. Additionally, it is utilized in tissue engineering to modify scaffolds for improved cell adhesion and growth. Its versatility makes it a key component in nanotechnology and biomedical research.