SH-PEG-SH is widely used in bioconjugation and surface modification due to its ability to form stable bonds with various molecules and materials. It is commonly applied in the development of drug delivery systems, where it acts as a linker to attach therapeutic agents to carriers like nanoparticles or liposomes, enhancing targeted delivery and reducing side effects. In tissue engineering, it is utilized to modify surfaces of scaffolds, improving cell adhesion and biocompatibility. Additionally, SH-PEG-SH plays a crucial role in creating biosensors by immobilizing biomolecules on sensor surfaces, ensuring high sensitivity and specificity. Its ability to form disulfide bonds also makes it valuable in designing redox-responsive materials for controlled release applications.