THP-SS-PEG1-Boc is used in pharmaceutical and biotechnology research for targeted drug delivery, bioconjugation, and nanotechnology applications. It serves as a versatile linker with a tetrahydropyranyl (THP)-protected hydroxyl group, a disulfide (SS) bond for redox-responsive cleavage, a short PEG1 chain to enhance water solubility, biocompatibility, and circulation time while reducing immunogenicity and rapid clearance, and a Boc-protected amine for temporary protection during synthesis, enabling controlled deprotection and site-specific conjugation.

The disulfide bond ensures stability under normal physiological conditions but allows precise release of active agents in reducing environments, such as intracellular glutathione. This structure is particularly valuable for modifying therapeutic agents, improving their stability and solubility in biological systems. Common applications include the development of antibody-drug conjugates (ADCs), protein and peptide therapeutics, prodrugs, functionalized nanoparticles, vaccines, and surface modification of biomaterials for controlled release and molecular imaging in medical diagnostics.