Used in bioconjugation to link proteins, peptides, or drugs through primary amine groups, forming stable amide bonds. Its star-shaped structure allows multi-directional coupling, enhancing stability and solubility of conjugated biomolecules. Commonly applied in drug delivery systems to prolong circulation time and reduce immunogenicity. Frequently used in crosslinking hydrogels for tissue engineering and wound healing due to its biocompatibility and tunable reactivity. Also utilized in surface modification of nanoparticles and medical devices to create non-fouling, hydrophilic coatings.