Hydroxy-PEG8-Boc is widely used in bioconjugation and drug delivery systems due to its water-soluble and biocompatible properties. It serves as a linker in the synthesis of peptide and protein conjugates, enabling controlled release and improved stability of therapeutic agents. The Boc (tert-butoxycarbonyl) group provides protection for amines during chemical reactions, allowing selective deprotection when needed. This compound is also utilized in the development of prodrugs, where it enhances solubility and bioavailability of hydrophobic drugs. Additionally, it plays a role in modifying surfaces of nanoparticles and biomaterials to improve their biocompatibility and targeting efficiency in biomedical applications.