Dimethylsilicone oil is widely used as a lubricant in various mechanical and industrial applications due to its excellent thermal stability, low viscosity, and chemical inertness. It is commonly applied in high-temperature environments, such as in the lubrication of bearings, gears, and other machinery components, where it helps reduce friction and wear. In the automotive industry, it also serves as a rust inhibitor for metal parts, extending engine life.

In the cosmetics and personal care industry, it is utilized as an emollient and conditioning agent in products like lotions, creams, sunscreens, and hair care formulations. It imparts a smooth, silky texture, enhances spreadability, adds shine, and protects hair from heat damage.

Additionally, it serves as a key ingredient in polishes and coatings, providing a protective, water-repellent layer on surfaces such as automotive finishes, furniture, and electronic components. In electronics, it acts as a moisture barrier and coating for circuit boards, preventing corrosion and improving device performance. Its ability to resist moisture and environmental degradation, including UV exposure, makes it ideal for these applications.

In the medical field, dimethylsilicone oil is used in certain surgical procedures, particularly in ophthalmology, as a tamponade agent to treat retinal detachments. Its inert nature and optical clarity make it suitable for such delicate applications. It is also employed in pharmaceuticals as a component in drug delivery systems for controlled release.

Lastly, it is employed as a release agent in manufacturing processes, such as in the production of rubber, plastics, and molded items, where it prevents sticking, ensures easy removal of finished products from molds, and enhances flexibility while protecting against heat and UV degradation. In the food industry, it functions as a lubricant for food-processing machinery.