Oleandrin is primarily researched for its potential use in cancer therapy due to its ability to inhibit the Na+/K+-ATPase pump, which can disrupt cellular functions and induce apoptosis in cancer cells. It has shown promise in preclinical studies for targeting certain types of cancers, including pancreatic and breast cancer. Additionally, oleandrin has been explored for its antiviral properties, particularly in inhibiting the replication of viruses such as HIV and SARS-CoV-2. Its anti-inflammatory effects are also being investigated for potential applications in treating chronic inflammatory conditions. However, its high toxicity limits its use, and further research is needed to develop safer derivatives or delivery methods.