Diethyl sebacate is used as a plasticizer in various polymers, particularly nitrocellulose, cellulose acetate, and synthetic rubbers, to enhance flexibility and low-temperature performance. It is commonly applied in coatings, adhesives, sealants, and printing inks to improve workability, adhesion, durability, and reduce foaming. In cosmetics and personal care products, it functions as an emollient, solvent, and fragrance fixative due to its low volatility and skin compatibility. Additionally, it serves as a lubricant additive and dye carrier in textile processing.