Used as a reference standard in analytical laboratories for the identification and quantification of caryophyllene oxide in essential oils, plant extracts, and cannabis samples. Commonly applied in quality control and research settings using gas chromatography (GC) or high-performance liquid chromatography (HPLC). Helps ensure accurate measurement of terpene profiles in natural products, supporting consistency in fragrance, flavor, and pharmaceutical formulations. Also utilized in studies exploring biological activity, such as anti-inflammatory or antimicrobial properties, where precise concentration is critical.