Used as a reference standard in analytical laboratories for the identification and quantification of caryophyllene oxide in essential oils, plant extracts, and natural product samples. Commonly applied in quality control processes for herbal medicines, aromatherapy products, and cannabis testing due to its presence as a natural sesquiterpene derivative. Enables accurate calibration of GC-MS and HPLC systems to ensure reliable detection in complex mixtures. Also utilized in research studying anti-inflammatory, antioxidant, and insecticidal properties of terpenoids.