Triethylamine trihydrofluoride is widely used in organic synthesis as a source of fluoride ions, particularly in reactions where anhydrous conditions are required. It is commonly employed in the cleavage of silicon-oxygen bonds, making it valuable in the deprotection of silyl ethers during the synthesis of complex organic molecules. Additionally, it serves as a fluorinating agent in the preparation of fluorinated compounds, which are important in pharmaceuticals, agrochemicals, and materials science. Its ability to dissolve metal oxides also makes it useful in etching processes in the electronics industry. Furthermore, it is utilized in the synthesis of peptides and nucleotides, where it aids in the removal of protecting groups without damaging sensitive functional groups.