Tetrabutylammonium fluoride trihydrate is widely used as a fluorinating agent in organic synthesis, particularly for introducing fluorine atoms into organic molecules. It is effective in desilylation reactions, where it removes silyl protecting groups from compounds, enabling further chemical modifications. This chemical is also employed in the preparation of ionic liquids and as a phase-transfer catalyst in various reactions, facilitating the transfer of reactants between immiscible phases. Additionally, it plays a role in the synthesis of pharmaceuticals and fine chemicals, contributing to the development of new drugs and materials. Its ability to act as a strong base and nucleophile makes it valuable in a range of chemical transformations.