OG 488,SE is widely used as a fluorescent labeling reagent in biological and biochemical applications. It reacts efficiently with primary amines on proteins, peptides, and other amine-containing molecules to form stable fluorescent conjugates. This makes it ideal for labeling antibodies, peptides, and nucleic acids for use in fluorescence microscopy, flow cytometry, and immunoassays. Its high fluorescence intensity and photostability allow for sensitive detection and imaging with low background. OG 488,SE is also cell-permeable in some contexts, enabling intracellular labeling when used with appropriate delivery methods. The succinimidyl ester (SE) group ensures rapid and specific conjugation under mild conditions, typically at physiological pH, making it compatible with a wide range of biomolecules without causing significant denaturation.