Ethyl 2-(9H-fluoren-9-yl)acetate serves as a versatile intermediate in organic synthesis, especially for constructing fluorene-based structures applied in pharmaceuticals, agrochemicals, and advanced functional materials. The fluorene core provides inherent fluorescence, rendering it useful in the creation of fluorescent probes, sensors, and conjugated polymers. The ethyl ester group facilitates straightforward modifications, such as hydrolysis to the acid or conversion to amides and alcohols, enhancing its utility in medicinal chemistry and materials science.