8-Prenylnaringenin is a potent phytoestrogen found in hops and beer, known for its strong estrogenic activity. It is primarily studied for its potential in managing menopausal symptoms such as hot flashes, night sweats, and bone loss due to its ability to bind to estrogen receptors. Research suggests it may support bone health by helping prevent osteoporosis through stimulation of osteoblast activity. It has also been explored for use in skincare products for its anti-aging properties, thanks to antioxidant and collagen-preserving effects. Due to its hormonal activity, it is used in some natural hormone replacement therapies and dietary supplements targeting women’s health. However, its use requires caution because of possible interactions with hormone-sensitive conditions.