O-Desmethylangolensin (O-DMA) is a metabolite produced by gut microbiota from plant isoflavones, particularly daidzein after consumption of soy-based foods. It has been studied for its weak estrogenic and anti-estrogenic activities, allowing it to interact with estrogen receptors in the body. This property suggests a potential role in modulating hormone-related conditions such as menopausal symptoms, osteoporosis, and certain hormone-dependent cancers like breast and prostate cancer.

Research indicates that O-DMA may contribute to cardiovascular health by improving endothelial function and reducing inflammation markers. Its presence in the bloodstream after dietary intake of phytoestrogens is also used as a biomarker for gut microbial metabolic activity and dietary compliance in nutritional studies.

Due to its origin from gut microbial transformation, levels of O-DMA vary significantly among individuals, reflecting differences in gut microbiome composition. This variability influences the effectiveness of plant-based diets in delivering health benefits, making O-DMA an important compound in personalized nutrition and microbiome research.