| Anti-inflammatory / “inflamm-aging” control |
In a 12-system human-cell phenotyping panel, 17 µM C 15:0 reduced key pro-inflammatory mediators (TNF-α, MCP-1, IL-17A/F) and inhibited mTOR while activating AMPK—activities comparable to rapamycin in scope PMC |
May calm redness, itching, and low-grade chronic inflammation that drives premature ageing or flare-ups (e.g. mild dermatitis, photo-irritation) |
| Membrane & barrier strengthening |
C 15:0 inserts into phospholipid bilayers, lowers lipid-peroxidation risk, and has been promoted for “locking in moisture” and restoring skin-barrier resiliency in consumer-facing reports The Chalkboard |
Acts as a saturated emollient that can cut transepidermal water loss (TEWL) and support suppleness—similar to shorter-chain fatty acids but with better oxidative stability |
| Antimicrobial / anti-biofilm |
• In vitro growth inhibition of Staphylococcus epidermidis, Klebsiella pneumoniae and Candida albicans PMC
• A C 15:0 coating prevented and destabilised mixed Candida–Klebsiella biofilms on polymer surfaces ResearchGate |
Adds preservative “boost” or helps keep micro-flora in check (useful in deodorants, acne or scalp products, wound/patch dressings) |
| Mitochondrial & antioxidant support |
Cell studies report ~45 % drop in reactive oxygen species (ROS) after C 15:0 treatment and improved mitochondrial function The Chalkboard |
May translate into better recovery from UV- or pollution-induced oxidative stress, supporting anti-ageing claims |
| Possible ceramide/long-chain lipid synthesis link |
Odd-chain fatty acids such as C 15:0 can be elongated or used as acyl donors; C 15 ceramide is commercially available for skin-lipid research, hinting at a role in SC lipid diversity Nature |
Potential to synergise with niacinamide or phytosphingosine to boost in-situ ceramide levels (needs validation) |
