tert-Butyl trimethylsilylacetate
≥95%(GC)
science Other reagents with same CAS 41108-81-0
blur_circular Chemical Specifications
description Product Description
Used as a versatile reagent in organic synthesis, particularly in the construction of complex molecules through carbon-carbon bond formation. It serves as a synthetic equivalent of a acetate anion, enabling homologation of carbonyl compounds. Commonly employed in silyl-modified Wittig-type reactions and Julia–Kocienski olefinations, it facilitates the preparation of α,β-unsaturated esters and alkenes with high stereoselectivity. Its silyl group stabilizes adjacent carbanions, enhancing reactivity under mild basic conditions. Widely applied in pharmaceutical and natural product synthesis where controlled chain elongation and functional group compatibility are critical.
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