tert-Butyl trimethylsilylacetate
≥95%(GC)
Reagent
Code: #154845
CAS Number
41108-81-0
blur_circular Chemical Specifications
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Molecular Information
Weight
188.34 g/mol
Formula
C₉H₂₀O₂Si
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Registry Numbers
MDL Number
MFCD00042855
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Storage & Handling
Storage
Room temperature, seal, dry, inert gas
description Product Description
Used as a versatile reagent in organic synthesis, particularly in the construction of complex molecules through carbon-carbon bond formation. It serves as a synthetic equivalent of a acetate anion, enabling homologation of carbonyl compounds. Commonly employed in silyl-modified Wittig-type reactions and Julia–Kocienski olefinations, it facilitates the preparation of α,β-unsaturated esters and alkenes with high stereoselectivity. Its silyl group stabilizes adjacent carbanions, enhancing reactivity under mild basic conditions. Widely applied in pharmaceutical and natural product synthesis where controlled chain elongation and functional group compatibility are critical.
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