Di-tert-butyl maleate is primarily used as a reactive intermediate in the synthesis of various polymers and resins. It is commonly employed in the production of coatings, adhesives, and sealants due to its ability to enhance flexibility and durability in the final product. Additionally, it serves as a crosslinking agent in the manufacturing of specialty plastics, improving their thermal and chemical resistance. In the pharmaceutical industry, it is utilized as a building block for the synthesis of certain active pharmaceutical ingredients (APIs). Its application in organic synthesis also extends to the creation of fine chemicals and additives for industrial processes.