A-395 is primarily utilized in biochemical research for its role as a selective inhibitor of the protein deacetylase SIRT6. This enzyme is involved in various cellular processes, including DNA repair, metabolism, and aging. By inhibiting SIRT6, A-395 helps scientists study the enzyme's function and its impact on these processes. It is particularly valuable in understanding the mechanisms of aging and age-related diseases, as well as exploring potential therapeutic targets for conditions like cancer and metabolic disorders. Additionally, A-395 is used in pharmacological studies to assess the effects of SIRT6 inhibition on cellular pathways and to develop novel treatments targeting this enzyme.