CP-319340 (free base) is primarily utilized in research settings as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme plays a critical role in the regulation of glucocorticoid metabolism, converting inactive cortisone to active cortisol. By inhibiting 11β-HSD1, CP-319340 helps reduce local cortisol levels, which is particularly relevant in studies focused on metabolic disorders, such as obesity, type 2 diabetes, and metabolic syndrome. Its application extends to exploring the role of glucocorticoids in inflammation, cognitive function, and cardiovascular health. Researchers also use it to investigate potential therapeutic strategies for conditions associated with excessive glucocorticoid activity.