MAC13772 is primarily utilized in biochemical research as a potent inhibitor of the ClpP protease, an enzyme critical for protein homeostasis in bacteria. Its application is significant in studying bacterial protein degradation pathways, particularly in understanding how inhibiting ClpP affects bacterial growth and survival. Researchers employ it to explore potential therapeutic strategies against bacterial infections, especially those caused by pathogens reliant on ClpP for virulence. Additionally, it serves as a tool compound in microbiology to dissect the role of proteases in cellular processes, aiding in the development of novel antibiotics targeting bacterial proteolytic systems.