BMS-303141 is primarily used in biochemical research as a potent and selective inhibitor of ATP-citrate lyase (ACL). This enzyme plays a critical role in fatty acid and cholesterol synthesis, making BMS-303141 a valuable tool for studying metabolic pathways. Researchers utilize it to investigate the effects of ACL inhibition on lipid metabolism, which can provide insights into conditions like obesity, diabetes, and cardiovascular diseases. Additionally, it is employed in cancer research to explore the role of ACL in tumor growth and proliferation, as cancer cells often rely on altered metabolic pathways for energy. Its application extends to drug discovery, where it helps in identifying potential therapeutic targets for metabolic disorders and cancer.