Autocamtide-2-related inhibitory peptide, myristoylated, is primarily used in research to study calcium/calmodulin-dependent protein kinase II (CaMKII) activity. It serves as a selective inhibitor of CaMKII, making it a valuable tool for understanding the role of this enzyme in various cellular processes. Researchers utilize it to investigate CaMKII's involvement in neuronal signaling, cardiac function, and memory formation. Its myristoylation enhances membrane association, allowing for targeted inhibition in specific cellular compartments. This peptide is particularly useful in experimental models exploring CaMKII's impact on diseases such as heart failure, arrhythmias, and neurological disorders.