Betrixaban maleate is primarily used as an anticoagulant to prevent blood clots in patients who are at high risk due to conditions such as acute medical illness. It is often prescribed for adults who are hospitalized and have limited mobility, reducing the risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). The medication works by inhibiting Factor Xa, a key component in the blood clotting process, thereby preventing the formation of clots. It is particularly beneficial for patients who cannot use other anticoagulants due to contraindications or side effects. Betrixaban maleate is typically administered orally, making it a convenient option for long-term prophylaxis in high-risk individuals.