Ro 48-8071
98%
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description Product Description
Used primarily in biochemical and pharmacological research, this compound acts as a potent inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. By inhibiting this enzyme, it effectively reduces cholesterol production in cells, making it a valuable tool for studying lipid metabolism and developing potential treatments for hypercholesterolemia and related cardiovascular diseases. It has been utilized in in vitro and in vivo studies to explore the consequences of blocked cholesterol synthesis, including effects on cell membrane integrity, steroid hormone production, and liver function. Additionally, due to its ability to lower cholesterol without affecting coenzyme Q or dolichol synthesis, it offers a selective mechanism that helps researchers understand the specific roles of cholesterol in biological systems. Preliminary research also suggests potential anti-cancer applications by disrupting sterol synthesis in abnormal cell proliferation, though its application remains largely confined to preclinical research settings.
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