Used in research as a specific inhibitor of the Mre11-Rad50-Nbs1 (MRN) complex, which plays a critical role in DNA damage response and repair. Mirin blocks the nuclease activity of Mre11, preventing the processing of DNA double-strand breaks. This inhibition leads to impaired activation of the ATM signaling pathway, a key regulator of cell cycle checkpoints and DNA repair. Commonly applied in studies involving genomic instability, cancer biology, and radiation sensitivity. Helps researchers dissect the mechanisms of DNA repair pathways and assess the potential of targeting MRN complex in anticancer therapies.