L-Buthionine-sulfoximine
10mM in Water
Reagent
Code: #201853
CAS Number
83730-53-4
blur_circular Chemical Specifications
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Molecular Information
Weight
222.31 g/mol
Formula
C₈H₁₈N₂O₃S
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Registry Numbers
MDL Number
MFCD00067000
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Physical Properties
Melting Point
224-228 °C(dec.)
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in research to inhibit glutathione synthesis by targeting the enzyme γ-glutamylcysteine synthetase. This inhibition leads to depletion of intracellular glutathione, making cells more susceptible to oxidative stress. Commonly applied in cancer research to sensitize tumor cells to chemotherapy and radiation. Also utilized in studies involving oxidative stress mechanisms, neurodegenerative diseases, and drug resistance in cell cultures. Its ability to modulate redox status makes it a valuable tool in experimental models exploring cellular defense systems.
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