Used in research to study gamma-glutamyl transpeptidase (GGT) activity, GGsTop acts as an irreversible inhibitor of the enzyme. It helps in understanding GGT's role in glutathione metabolism, oxidative stress, and inflammation. Commonly applied in cellular and animal models to probe GGT-related pathways, it supports investigations into liver disease, cancer progression, and drug resistance. Its selectivity makes it valuable for validating GGT as a therapeutic target and for developing imaging agents or treatments aimed at GGT-expressing tissues.