OGG1 inhibitor O8 is primarily utilized in research settings to study the role of the OGG1 enzyme in DNA repair mechanisms. By inhibiting OGG1, researchers can investigate how the enzyme contributes to the repair of oxidative DNA damage, particularly the removal of 8-oxoguanine lesions. This helps in understanding the cellular responses to oxidative stress and the potential implications in diseases such as cancer, neurodegenerative disorders, and aging. Additionally, OGG1 inhibitor O8 is used to explore the enzyme's involvement in inflammatory processes, as OGG1 has been linked to the activation of certain inflammatory pathways. Its application is crucial in developing targeted therapies that modulate DNA repair and inflammation.