PF-915275 is primarily utilized in research settings as a potent and selective inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme plays a crucial role in the regulation of cortisol levels within tissues, and its inhibition is of significant interest in the study of metabolic disorders. By blocking 11β-HSD1, PF-915275 helps reduce local cortisol production, which is beneficial in investigating conditions such as obesity, type 2 diabetes, and metabolic syndrome. Its application extends to preclinical studies aimed at understanding the role of cortisol in insulin resistance and glucose metabolism. Additionally, it serves as a valuable tool in pharmacological research to explore the therapeutic potential of 11β-HSD1 inhibitors in managing these metabolic diseases.