MLS0315771 is a potent and selective small-molecule inhibitor of the YAP/TAZ-TEAD interaction, a key component of the Hippo signaling pathway. It is primarily used in preclinical research to investigate cellular proliferation, apoptosis, and tissue homeostasis, with significant applications in oncology for studying tumor growth and metastasis. This compound helps elucidate the role of dysregulated Hippo pathway in cancers such as liver, breast, and lung tumors. Additionally, it shows potential in fibrosis and regenerative medicine research. As a research tool, MLS0315771 enables precise modulation of TEAD transcription factors, aiding in the discovery of novel therapeutic targets. Further studies are required to explore its clinical translation.