Used in the synthesis of complex natural products and bioactive molecules, particularly in pharmaceutical research targeting enzyme inhibitors or receptor modulators. Its structural complexity, including stereochemistry and functional groups like the iodinated alkene and pivalate ester, makes it a valuable intermediate in asymmetric synthesis and fragment coupling reactions. Commonly employed in late-stage functionalization due to the reactivity of the iodine moiety, enabling cross-coupling reactions such as Suzuki or Heck reactions. The tetrahydrofuran core with defined stereocenters also supports its use in constructing chiral building blocks for drug development.