SNX-2112 (PF-04928473)
10mM in DMSO
Reagent
Code: #234049
CAS Number
908112-43-6
science Other reagents with same CAS 908112-43-6
blur_circular Chemical Specifications
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Molecular Information
Weight
464.48 g/mol
Formula
C₂₃H₂₇F₃N₄O₃
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Registry Numbers
MDL Number
MFCD16038907
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Storage & Handling
Storage
-20°C
description Product Description
SNX-2112 is primarily investigated for its potential in cancer therapy, specifically as a selective inhibitor of heat shock protein 90 (Hsp90). Hsp90 plays a critical role in stabilizing various oncoproteins that drive tumor growth and survival. By inhibiting Hsp90, SNX-2112 promotes the degradation of these client proteins, leading to suppression of cancer cell proliferation and induction of apoptosis.
It has shown preclinical activity against a range of cancers, including breast, lung, and prostate cancers, especially in tumors dependent on Hsp90-regulated signaling pathways such as HER2, AKT, and mutant BRAF. Due to its ability to simultaneously disrupt multiple oncogenic pathways, SNX-2112 is considered a promising candidate for overcoming resistance to single-target therapies.
Research has also explored its use in combination with other anticancer agents to enhance therapeutic efficacy. While still largely in experimental stages, SNX-2112 contributes to the development of targeted cancer treatments with a broad mechanism of action.
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