PJ34 HCl

10mM in DMSO

Reagent Code: #224124
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CAS Number 344458-15-7

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 331.80 g/mol
Formula C₁₇H₁₇N₃O₂·HCl
inventory_2 Storage & Handling
Storage -20°C

description Product Description

Used primarily in scientific research, this compound acts as a potent inhibitor of PARP-1 and PARP-2 enzymes, which play key roles in DNA repair mechanisms. It is widely applied in studies related to cellular responses to DNA damage, particularly in cancer research. By blocking PARP activity, it enhances the cytotoxic effects of DNA-damaging agents, making it useful in exploring combination therapies with chemotherapy or radiation. It has also been investigated in models of ischemia-reperfusion injury, such as in heart attack and stroke, where inhibition of PARP shows protective effects. Additionally, it is used in aging and neurodegeneration studies due to its role in modulating cellular stress pathways. Its application remains limited to laboratory and preclinical settings, with no approved clinical use in humans.

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inventory 1ml
10-20 days ฿5,140.00

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