Used in research for enhancing the effectiveness of alkylating agents in cancer therapy by inhibiting the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). This inhibition helps prevent tumor cells from repairing DNA damage induced by chemotherapy, thereby increasing cancer cell death. Investigated primarily in combination with drugs like temozolomide for treating resistant tumors, including gliomas and melanomas. Shows potential in overcoming chemoresistance in malignancies with high AGT expression.