3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione

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Reagent Code: #192356
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CAS Number 2304754-51-4

science Other reagents with same CAS 2304754-51-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 338.16 g/mol
Formula C₁₃H₁₂BrN₃O₃
badge Registry Numbers
MDL Number MFCD34183045
thermostat Physical Properties
Boiling Point 516.6±50.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.670±0.06 g/cm3(Predicted)
Storage Room temperature, seal, inert gas

description Product Description

Used in pharmaceutical research as a potent and selective inhibitor of cereblon (CRBN), this compound plays a key role in the development of targeted protein degradation therapies. It serves as a key intermediate in synthesizing analogs of thalidomide and lenalidomide, modified to enhance binding affinity and specificity. Due to its ability to modulate CRBN activity, it is investigated for use in treating hematological cancers such as multiple myeloma and myelodysplastic syndromes. Additionally, its bromo-functionalized aromatic core allows for further chemical derivatization via cross-coupling reactions, enabling rapid exploration of structure-activity relationships in drug discovery programs.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿1,380.00
inventory 1g
10-20 days ฿11,520.00
inventory 5g
10-20 days ฿49,240.00
inventory 250mg
10-20 days ฿2,920.00
inventory 10g
10-20 days ฿82,050.00

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3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione
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Used in pharmaceutical research as a potent and selective inhibitor of cereblon (CRBN), this compound plays a key role in the development of targeted protein degradation therapies. It serves as a key intermediate in synthesizing analogs of thalidomide and lenalidomide, modified to enhance binding affinity and specificity. Due to its ability to modulate CRBN activity, it is investigated for use in treating hematological cancers such as multiple myeloma and myelodysplastic syndromes. Additionally, its bromo-functionalized aromatic core allows for further chemical derivatization via cross-coupling reactions, enabling rapid exploration of structure-activity relationships in drug discovery programs.
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