3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione
97%
Reagent
Code: #192356
CAS Number
2304754-51-4
science Other reagents with same CAS 2304754-51-4
blur_circular Chemical Specifications
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Molecular Information
Weight
338.16 g/mol
Formula
C₁₃H₁₂BrN₃O₃
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Registry Numbers
MDL Number
MFCD34183045
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Physical Properties
Boiling Point
516.6±50.0 °C(Predicted)
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Storage & Handling
Density
1.670±0.06 g/cm3(Predicted)
Storage
Room temperature, seal, inert gas
description Product Description
Used in pharmaceutical research as a potent and selective inhibitor of cereblon (CRBN), this compound plays a key role in the development of targeted protein degradation therapies. It serves as a key intermediate in synthesizing analogs of thalidomide and lenalidomide, modified to enhance binding affinity and specificity. Due to its ability to modulate CRBN activity, it is investigated for use in treating hematological cancers such as multiple myeloma and myelodysplastic syndromes. Additionally, its bromo-functionalized aromatic core allows for further chemical derivatization via cross-coupling reactions, enabling rapid exploration of structure-activity relationships in drug discovery programs.
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