A-286982 is a selective inhibitor of the plasma membrane Ca²⁺ ATPase (PMCA), primarily utilized in research and development within the pharmaceutical and biomedical industries. It is particularly employed in the study of calcium homeostasis and its role in neurodegeneration, aiding investigations into enzyme inhibition related to neuronal health. As a tool compound, it helps explore biological pathways and mechanisms involved in diseases such as Alzheimer's and Parkinson's, contributing to the discovery of potential therapeutic targets. Its applications extend to preclinical studies for understanding disease models and evaluating drug candidates, as well as biochemical assays to assess specificity and potency in modulating cellular calcium processes, advancing drug design for neurological disorders.