Polyphenylsulfone is widely used in high-performance engineering applications due to its excellent thermal stability, mechanical strength, and resistance to hydrolysis and chemicals. It is commonly employed in the aerospace and automotive industries for components that must withstand high temperatures and harsh environments, such as structural parts, electrical insulators, and under-the-hood components.

In the medical field, it is used for surgical instruments and sterilization trays because it can endure repeated autoclave cycles without degrading. Its transparency to radiation also makes it suitable for radiation sterilization processes.

Polyphenylsulfone is also utilized in food processing and semiconductor manufacturing equipment, where dimensional stability, purity, and resistance to cleaning agents are critical. Additionally, it serves as a matrix material in advanced composites and as a membrane material in filtration systems requiring high durability.