Polyphenylsulfone is widely used in applications requiring high thermal stability, excellent mechanical strength, and resistance to hydrolysis and steam. It is commonly employed in medical devices and equipment that undergo repeated sterilization, such as surgical instruments and diagnostic components, due to its ability to withstand autoclave conditions without degrading.

In the aerospace and automotive industries, it serves as a lightweight, durable material for interior components, connectors, and structural parts exposed to high temperatures. Its inherent flame resistance and low smoke emission make it suitable for use in mass transit systems and aircraft interiors.

Polyphenylsulfone is also utilized in food processing equipment because it maintains integrity under high-temperature cleaning processes and complies with food safety standards. Additionally, it is used in membranes for water purification and filtration systems, where chemical resistance and long-term stability are critical.