R-Palmitoyl-(1-methyl) Ethanolamide (R-1 PMA) is primarily used in the cosmetic and skincare industry due to its moisturizing and skin barrier-enhancing properties. It is often incorporated into formulations such as creams, lotions, and serums to improve skin hydration and elasticity. The compound helps to reinforce the skin's natural lipid barrier, making it effective in treating dry or sensitive skin conditions. Additionally, it is utilized in anti-aging products for its ability to promote skin firmness and reduce the appearance of fine lines and wrinkles. Its compatibility with other skincare ingredients makes it a versatile component in various dermatological and cosmetic applications.

Furthermore, it is applied in hair care products to increase smoothness and reduce hair breakage and loss, resulting in healthier and more vibrant hair.

In the pharmaceutical sector, R-1 PMA is under study for its potential to alleviate skin inflammation and irritation, potentially serving as an ingredient in creams or gels for treating various skin issues, such as redness or sensitive skin.