PD-159020 is primarily used in research settings to study the mechanisms of cell signaling, particularly in the context of cancer biology. It acts as a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, which plays a critical role in cell proliferation and survival. By blocking EGFR activity, this compound helps researchers understand the pathways involved in tumor growth and resistance to therapies. Its application extends to preclinical studies where it is used to evaluate the efficacy of EGFR-targeted treatments in various cancer models. Additionally, PD-159020 serves as a valuable tool in developing new therapeutic strategies aimed at inhibiting EGFR-driven cancers.