HM30181 is primarily utilized in the field of medical research, particularly in the study of drug efflux mechanisms. It is known for its role as a potent inhibitor of P-glycoprotein (P-gp), a protein that plays a significant role in multidrug resistance (MDR) in cancer cells. By inhibiting P-gp, HM30181 helps to enhance the efficacy of chemotherapeutic agents, making it a valuable tool in oncology research. This compound is often used in preclinical studies to investigate ways to overcome drug resistance in various cancer treatments, thereby improving the therapeutic outcomes of existing anticancer drugs.